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Fung, John

One or more keywords matched the following properties of Fung, John

Property	Value
keywords	Immunosuppressive Agents
overview	John J. Fung, M.D., Ph.D. is the Director of the UChicago Medicine Transplantation Institute. Prior to that, he served as Chairman of the Cleveland Clinic Health System Center for Transplantation, as well as the former Chief of the Division of Transplant Surgery at the University of Pittsburgh. With over 30 years of involvement in abdominal and cellular transplantation, he is also an accomplished immunologist. Dr. Fung received his B.A. from the Johns Hopkins University in 1975, followed by a Ph.D. in Immunology in 1980 and M.D. in 1982 from the University of Chicago. He completed his surgical residency at the University of Rochester, and a transplant surgery fellowship at the University of Pittsburgh, under the guidance of Dr. Thomas Starzl. Between 1987 and 1988, he served as Director of Histocompatibility Testing at the University of Rochester. In 1989, he joined the faculty at the University of Pittsburgh and held the tenured position as the inaugural Thomas E. Starzl Professor in Surgery. He joined the Cleveland Clinic in 2004 as the Chairman of the Department of General Surgery and Professor of Surgery at the Lerner College of Medicine at Case Western University. He also served as the Medical Director of Allogen Laboratory, one of the largest histocompatibility laboratories in the United States and oversaw transplantation services at five Cleveland Clinic facilities globally. In 2016, he was recruited to serve as the Director of the newly created University of Chicago Medicine Transplantation Institute. Dr. Fung is a member of numerous scientific and surgical societies and served as President of the International Liver Transplantation Society from 1997-1999. He is currently Secretary of the Transplantation Society. He has published over 1,000 articles and book chapters and serves on the editorial board for several medical journals. He is the immediate past Editor-in-Chief for Liver Transplantation, the highest impact factor specialty transplant journal. His principal research interests are in transplantation immunology, immunosuppressive therapies, and liver related immunology. In addition, he has received numerous prestigious lay and professional awards. His research interests are in transplant immunology, liver immunity, immnosuppression, and outcomes analysis. Dr. Fung is active in community affairs and has been a member of the Board of Directors at the Americans for Medical Progress and the Gift of Hope Organ Procurement Organization. He received an honorable discharge from the United States Army Reserve Medical Corps with the rank of Lieutenant Colonel. He and his wife, Beth have four children: Justin, Lauren, Brendan and Shannon.

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Immunosuppressive Agents

overview

John J. Fung, M.D., Ph.D. is the Director of the UChicago Medicine Transplantation Institute. Prior to that, he served as Chairman of the Cleveland Clinic Health System Center for Transplantation, as well as the former Chief of the Division of Transplant Surgery at the University of Pittsburgh. With over 30 years of involvement in abdominal and cellular transplantation, he is also an accomplished immunologist. Dr. Fung received his B.A. from the Johns Hopkins University in 1975, followed by a Ph.D. in Immunology in 1980 and M.D. in 1982 from the University of Chicago. He completed his surgical residency at the University of Rochester, and a transplant surgery fellowship at the University of Pittsburgh, under the guidance of Dr. Thomas Starzl. Between 1987 and 1988, he served as Director of Histocompatibility Testing at the University of Rochester. In 1989, he joined the faculty at the University of Pittsburgh and held the tenured position as the inaugural Thomas E. Starzl Professor in Surgery. He joined the Cleveland Clinic in 2004 as the Chairman of the Department of General Surgery and Professor of Surgery at the Lerner College of Medicine at Case Western University. He also served as the Medical Director of Allogen Laboratory, one of the largest histocompatibility laboratories in the United States and oversaw transplantation services at five Cleveland Clinic facilities globally. In 2016, he was recruited to serve as the Director of the newly created University of Chicago Medicine Transplantation Institute. Dr. Fung is a member of numerous scientific and surgical societies and served as President of the International Liver Transplantation Society from 1997-1999. He is currently Secretary of the Transplantation Society. He has published over 1,000 articles and book chapters and serves on the editorial board for several medical journals. He is the immediate past Editor-in-Chief for Liver Transplantation, the highest impact factor specialty transplant journal. His principal research interests are in transplantation immunology, immunosuppressive therapies, and liver related immunology. In addition, he has received numerous prestigious lay and professional awards. His research interests are in transplant immunology, liver immunity, immnosuppression, and outcomes analysis. Dr. Fung is active in community affairs and has been a member of the Board of Directors at the Americans for Medical Progress and the Gift of Hope Organ Procurement Organization. He received an honorable discharge from the United States Army Reserve Medical Corps with the rank of Lieutenant Colonel. He and his wife, Beth have four children: Justin, Lauren, Brendan and Shannon.

One or more keywords matched the following items that are connected to Fung, John

Item Type	Name
Concept	Adjuvants, Immunologic
Concept	Acquired Immunodeficiency Syndrome
Concept	Immunoglobulin M
Concept	Dose-Response Relationship, Immunologic
Concept	Cytotoxicity, Immunologic
Concept	Cytotoxicity Tests, Immunologic
Concept	Growth Inhibitors
Concept	Enzyme Inhibitors
Concept	Immunoglobulin A
Concept	Immunologic Factors
Concept	Graft Enhancement, Immunologic
Concept	Dose-Response Relationship, Drug
Concept	Immune Sera
Concept	Immune Tolerance
Concept	Immunotherapy
Concept	Enzyme-Linked Immunosorbent Assay
Concept	Immunity, Cellular
Concept	Immunoglobulin Isotypes
Concept	Immunohistochemistry
Concept	Protease Inhibitors
Concept	Immunoglobulin G
Concept	Immune Complex Diseases
Concept	Immunization, Passive
Concept	Immunoassay
Concept	Immunoelectrophoresis
Concept	Immunoenzyme Techniques
Concept	Immunoglobulin D
Concept	Immunization
Concept	Immunoglobulin lambda-Chains
Concept	Immunoglobulin mu-Chains
Concept	Transplantation Immunology
Concept	Reverse Transcriptase Inhibitors
Concept	Immunocompromised Host
Concept	Immunotherapy, Adoptive
Concept	Models, Immunological
Concept	Immunoconjugates
Concept	Cyclin-Dependent Kinase Inhibitor p21
Concept	Monitoring, Immunologic
Concept	Immunomodulation
Concept	AIDS-Related Opportunistic Infections
Concept	Immunoglobulins, Intravenous
Concept	HIV Protease Inhibitors
Concept	TNF-Related Apoptosis-Inducing Ligand
Concept	Immunity
Concept	Immunoglobulins
Concept	Immunoglobulin kappa-Chains
Concept	Immunologic Memory
Concept	Immunologic Techniques
Concept	Immunophenotyping
Academic Article	Outcomes of liver transplant recipients with hepatitis C and human immunodeficiency virus coinfection.
Academic Article	Tacrolimus rescue therapy for renal transplant rejection.
Academic Article	Conversion from tacrolimus to cyclosporine--a based immunosuppression following liver transplantation.
Academic Article	Augmentation of natural chimerism with donor bone marrow in orthotopic liver recipients.
Academic Article	Tolerogenic immunosuppression for organ transplantation.
Academic Article	Cotransplanted hepatic stellate cells enhance vascularization of islet allografts.
Academic Article	Non-lymphoid cancer after liver transplantation.
Academic Article	Chimerism after organ transplantation.
Academic Article	Immune complex disease in immunosuppressed rat recipients of hamster liver xenografts.
Academic Article	Combined liver-kidney transplants: allosensitization and recipient outcomes.
Academic Article	Small bowel transplantation: current progress and clinical application.
Academic Article	The bidirectional paradigm of transplant immunology.
Academic Article	Prolongation of cardiac allograft survival by systemic administration of immature recipient dendritic cells deficient in NF-kappaB activity.
Academic Article	Evaluation of the influence of FK 506, rapamycin, and cyclosporine on processing and presentation of particulate antigen by macrophages: assessment of a drug "carry-over" effect.
Academic Article	FK 506 versus cyclosporine in pediatric liver transplantation.
Academic Article	Posttransplant lymphoproliferative disorders occurring under primary FK 506 immunosuppression.
Academic Article	Clonal and morphological variation in a posttransplant lymphoproliferative disorder: evolution from clonal T-cell to clonal B-cell predominance.
Academic Article	A prospective randomized trial of tacrolimus and prednisone versus tacrolimus, prednisone and mycophenolate mofetil in primary adult liver transplantation: a single center report.
Academic Article	Analysis of T lymphocytes infiltrating human hepatic allografts.
Academic Article	Porcine cell microchimerism but lack of productive porcine endogenous retrovirus (PERV) infection in naive and humanized SCID-beige mice treated with porcine peripheral blood mononuclear cells.
Academic Article	Mechanisms underlying the development of T-cell tolerance following interruption of signalling at the CD28/B7 and CD40/gp39 interface.
Academic Article	Immunopathology of antibodies as effectors of orthotopic liver allograft rejection.
Academic Article	Composition of human islet cell preparations for transplantation.
Academic Article	Liver graft induced donor specific unresponsiveness without class I and/or class II antigen differences.
Academic Article	Strategy of FK 506 therapy in liver transplant patients: effect of graft function.
Academic Article	Viable strategies to facilitate liver transplantation for human immunodeficiency virus coinfection.
Academic Article	A critical role of TRAIL expressed on cotransplanted hepatic stellate cells in prevention of islet allograft rejection.
Academic Article	Prevention of de novo hepatitis B infection in recipients of hepatic allografts from anti-HBc positive donors.
Academic Article	Perioperative treatment with phosphatidic acid inhibitor (Lisofylline leads to prolonged survival of hearts in the guinea pig to rat xenotransplant model.
Academic Article	Mechanistic insights into immunomodulation by hepatic stellate cells in mice: a critical role of interferon-gamma signaling.
Academic Article	Renal retransplantation in elderly recipients under tacrolimus-based immunosuppression.
Academic Article	EBV-specific memory CD8+ T cell phenotype and function in stable solid organ transplant patients.
Academic Article	Tacrolimus rescue therapy for renal allograft rejection--five-year experience.
Academic Article	The University of Pittsburgh: a three and three-quarter-year experience with cadaveric renal transplantation under the point system.
Academic Article	De novo sirolimus and reduced-dose tacrolimus versus standard-dose tacrolimus after liver transplantation: the 2000-2003 phase II prospective randomized trial.
Academic Article	Cardiac changes at autopsy in adult liver transplant recipients under tacrolimus.
Academic Article	Ex vivo priming of naïve T cells into EBV-specific Th1/Tc1 effector cells by mature autologous DC loaded with apoptotic/necrotic LCL.
Academic Article	Pharmacokinetics of mycophenolic acid after mycophenolate mofetil administration in liver transplant patients treated with tacrolimus.
Academic Article	Reduction of primary nonfunction with prostaglandin E1 after clinical liver transplantation.
Academic Article	Liver-derived DEC205+B220+CD19- dendritic cells regulate T cell responses.
Academic Article	Liver-derived dendritic cells induce donor-specific hyporesponsiveness: use of sponge implant as a cell transplant model.
Academic Article	Primary tacrolimus (FK506) therapy and the long-term risk of post-transplant lymphoproliferative disease in pediatric liver transplant recipients.
Academic Article	Mechanistic insights into achievement of cardiac allograft long-term survival by treatment with immature dendritic cells and sub-dose sirolimus.
Academic Article	Tacrolimus enhances the immunosuppressive effect of cyclophosphamide but not that of leflunomide or mycophenolate mofetil in a model of discordant liver xenotransplantation.
Academic Article	Costimulation blockade promotes the apoptotic death of graft-infiltrating T cells and prolongs survival of hepatic allografts from FLT3L-treated donors.
Academic Article	Donor species complement after liver xenotransplantation. The mechanism of protection from hyperacute rejection.
Academic Article	State of immunosuppressive agents in organ transplantation.
Academic Article	Systemic administration of CTLA4-Ig or anti-CD40 ligand antibody inhibits second-set rejection of mouse liver allografts.
Academic Article	Use of alemtuzumab and tacrolimus monotherapy for cadaveric liver transplantation: with particular reference to hepatitis C virus.
Academic Article	Adverse effects associated with the use of FK 506.
Academic Article	The interaction between antiretroviral agents and tacrolimus in liver and kidney transplant patients.
Academic Article	Clinical intestinal transplantation.
Academic Article	Survival of liver transplant patients coinfected with HIV and HCV is adversely impacted by recurrent hepatitis C.
Academic Article	The Pittsburgh randomized trial of tacrolimus compared to cyclosporine for hepatic transplantation.
Academic Article	Kidney transplantation under minimal immunosuppression after pretransplant lymphoid depletion with Thymoglobulin or Campath.
Academic Article	Orthotopic liver transplantation in U.S. veterans under primary tacrolimus immunosupression.
Academic Article	Measurement of CD4+ T-cell function in predicting allograft rejection and recurrent hepatitis C after liver transplantation.
Academic Article	Longitudinal study of cryptococcosis in adult solid-organ transplant recipients.
Academic Article	Weaning of immunosuppression in liver transplant recipients.
Academic Article	CMV infection in liver transplantation under cyclosporine or FK 506 immunosuppression.
Academic Article	Allogeneic hematolymphoid microchimerism and prevention of autoimmune disease in the rat. A relationship between allo- and autoimmunity.
Academic Article	Increased apoptosis of immunoreactive host cells and augmented donor leukocyte chimerism, not sustained inhibition of B7 molecule expression are associated with prolonged cardiac allograft survival in mice preconditioned with immature donor dendritic cells plus anti-CD40L mAb.
Academic Article	Xenotransplantation of hamster liver into Gunn rats reserves congenital hyperbilirubinemia.
Academic Article	Maturation of B-cell clones.
Academic Article	Augmentation of type-1 polarizing ability of monocyte-derived dendritic cells from chronically immunosuppressed organ-transplant recipients.
Academic Article	In vivo expansion of two distinct dendritic cells in mouse livers and its impact on liver immune regulation.
Academic Article	Induction of tumor immunity and cytotoxic t lymphocyte responses using dendritic cells transduced by adenoviral vectors encoding HBsAg: comparison to protein immunization.
Academic Article	A clinical trial combining donor bone marrow infusion and heart transplantation: intermediate-term results.
Academic Article	The two-way paradigm of transplantation immunology.
Academic Article	Clinical small bowel or small bowel plus liver transplantation under FK 506.
Academic Article	Infusion of donor leukocytes to induce tolerance in organ allograft recipients.
Academic Article	In vivo immune modulatory activity of hepatic stellate cells in mice.
Academic Article	Ribavirin dose modification based on renal function is necessary to reduce hemolysis in liver transplant patients with hepatitis C virus infection.
Academic Article	Patient participation in research among solid organ transplant recipients in the United States.
Academic Article	Costimulatory molecule-deficient dendritic cell progenitors (MHC class II+, CD80dim, CD86-) prolong cardiac allograft survival in nonimmunosuppressed recipients.
Academic Article	Pancreas transplantation under alemtuzumab (Campath-1H) and tacrolimus: Correlation between low T-cell responses and infection.
Academic Article	Chronic liver allograft rejection in a population treated primarily with tacrolimus as baseline immunosuppression: long-term follow-up and evaluation of features for histopathological staging.
Academic Article	Evidence of microchimerism after pretransplant blood transfusion and FK 506 in liver xenograft.
Academic Article	Prevention of sensitization and hyperacute rejection in liver and heart xenografts by FK 506 plus donor antigens.
Academic Article	Central venulitis in the allograft liver: a clinicopathologic study.
Academic Article	Donor bone marrow infusion in liver recipients: effect on the occurrence of acute cellular rejection.
Academic Article	Outcome of kidney transplantation in African-Americans using tacrolimus.
Academic Article	A randomized trial of inhaled cyclosporine in lung-transplant recipients.
Academic Article	The pharmacodynamics of pentobarbital following FK 506 therapy.
Academic Article	Clinical intestinal transplantation in 1998: Pittsburgh experience.
Academic Article	The effect of cyclosporine, rapamycin and FK 506 the survival following allogeneic bone marrow transplantation.
Academic Article	Liver allograft rejection in sensitized recipients. Observations in a clinically relevant small animal model.
Academic Article	Cell migration and chimerism after whole-organ transplantation: the basis of graft acceptance.
Academic Article	Pseudallescheria boydii (Anamorph Scedosporium apiospermum). Infection in solid organ transplant recipients in a tertiary medical center and review of the literature.
Academic Article	Adenosine Increases Hepatic Artery Flow in Liver Transplant Recipients: A Pilot Study.
Academic Article	FK506 in solid organ transplantation.
Academic Article	Hepatic stellate cells regulate immune response by way of induction of myeloid suppressor cells in mice.
Academic Article	Prolonged survival of hearts obtained from chimeric donors in a mouse to rat xenotransplant model.
Academic Article	Daily serum interleukin-6 monitoring in multiple organ transplantation with or without liver allografts.
Academic Article	Results of pancreas transplantation after steroid withdrawal under tacrolimus immunosuppression.
Academic Article	Impact of De Novo and Preexisting Inflammatory Bowel Disease on the Outcome of Orthotopic Liver Transplantation.
Academic Article	Immune cell function testing: an adjunct to therapeutic drug monitoring in transplant patient management.
Academic Article	Xenogeneic humoral graft-Vs-host disease following hamster-to-Rat bone marrow transplantation.
Academic Article	Growth factor-induced mobilization of dendritic cells in kidney and liver of rhesus macaques: implications for transplantation.
Academic Article	The impact of positive T-cell lymphocytotoxic crossmatch on intestinal allograft rejection and survival.
Academic Article	Incidence of de novo cancer and lymphoproliferative disorders after liver transplantation in relation to age and duration of follow-up.
Academic Article	Long-term follow-up of tacrolimus rescue therapy for renal allograft rejection.
Academic Article	Risks and benefits of weaning immunosuppression in liver transplant recipients: long-term follow-up.
Academic Article	Enteric-drained pancreas transplants monitored by fine-needle aspiration biopsy.
Academic Article	ICAM-1 expressed on hepatic stellate cells plays an important role in immune regulation.
Academic Article	Ex vivo generation of effective Epstein-Barr virus (EBV)-specific CD8+ cytotoxic T lymphocytes from the peripheral blood of immunocompetent Epstein Barr virus-seronegative individuals.
Academic Article	Autologous lymphokine-activated killer cell therapy of Epstein-Barr virus-positive and -negative lymphoproliferative disorders arising in organ transplant recipients.
Academic Article	Hematolymphoid cell trafficking, microchimerism, and GVH reactions after liver, bone marrow, and heart transplantation.
Academic Article	Complement and target cells belong to the same species after liver xenografting: protection from hyperacute rejection.
Academic Article	"Suboptimal" kidney donors: the experience with tacrolimus-based immunosuppression.
Academic Article	Rapamycin: friend, foe, or misunderstood?
Academic Article	The long-term efficacy of multivisceral transplantation.
Academic Article	Five-year experience with tacrolimus rescue for renal allograft rejection.
Academic Article	Apoptosis of graft-infiltrating cytotoxic T cells: a mechanism underlying "split tolerance" in mouse liver transplantation.
Academic Article	Augmentation of chimerism with perioperative donor bone marrow infusion in organ transplant recipients: a 44 month follow-up.
Academic Article	Donor-specific transfusion in the nude rat prolongs survival of subsequently transplanted hamster cardiac xenografts.
Academic Article	FK506 "rescue" for resistant rejection of renal allografts under primary cyclosporine immunosuppression.
Academic Article	Long-term outcome of adding mycophenolate mofetil to tacrolimus for nephrotoxicity following liver transplantation.
Academic Article	Does tacrolimus offer virtual freedom from chronic rejection after primary liver transplantation? Risk and prognostic factors in 1,048 liver transplantations with a mean follow-up of 6 years.
Academic Article	Caroli's disease and orthotopic liver transplantation.
Academic Article	The role of antibodies in liver graft-induced tolerance in mice: passive transfer of serum and effect of recipient B-cell depletion.
Academic Article	Explanation for loss of the HLA matching effect.
Academic Article	Kaposi's sarcoma in liver transplant recipients on FK506.
Academic Article	Combined liver-kidney transplantation and the effect of preformed lymphocytotoxic antibodies.
Academic Article	Tacrolimus and transplantation: a decade in review.
Academic Article	Induction of donor-specific transplantation tolerance to skin and cardiac allografts using mixed chimerism in (A + B-->A) in rats.
Academic Article	A prospective, randomized trial of tacrolimus/prednisone versus tacrolimus/prednisone/mycophenolate mofetil in renal transplant recipients.
Academic Article	Immunosuppressive therapy.
Academic Article	Temporary withdrawal of immunosuppression for life-threatening infections after liver transplantation.
Academic Article	Prolonged survival of islet allografts following combined therapy with tacrolimus and leflunomide.
Academic Article	Transduction of dendritic cells with adenoviral vectors encoding CTLA4-Ig markedly reduces their allostimulatory activity.
Academic Article	Correlation of rejection episodes with FK 506 dosage, FK 506 level, and steroids following primary orthotopic liver transplant.
Academic Article	Neurologic complications of FK 506.
Academic Article	Living-related donor renal transplantation in HIV+ recipients using alemtuzumab preconditioning and steroid-free tacrolimus monotherapy: a single center preliminary experience.
Academic Article	An analysis of pretransplantation variables associated with long-term allograft outcome in pediatric liver transplant recipients receiving primary tacrolimus (FK506) therapy.
Academic Article	Pretreatment of recipients (nude rat) with donor antigens leads to prolonged survival of hamster heart xenografts.
Academic Article	Orthotopic liver transplantation for patients with hepatitis B virus-related liver disease.
Academic Article	Tacrolimus pretreatment attenuates preexisting xenospecific immunity and abrogates hyperacute rejection in a presensitized hamster to rat liver transplant model.
Academic Article	Lack of killer immunoglobulin-like receptor 2DS2 (KIR2DS2) and KIR2DL2 is associated with poor responses to therapy of recurrent hepatitis C virus in liver transplant recipients.
Academic Article	Impact of donor MHC class I or class II antigen deficiency on first- and second-set rejection of mouse heart or liver allografts.
Academic Article	Immunological quantitation and localization of ACAT-1 and ACAT-2 in human liver and small intestine.
Academic Article	The role of liver-derived regulatory dendritic cells in prevention of type 1 diabetes.
Academic Article	The absence of chronic rejection in pediatric primary liver transplant patients who are maintained on tacrolimus-based immunosuppression: a long-term analysis.
Academic Article	Administration of CTLA4-Ig enhances the incidence of hamster-to-rat xenogeneic bone marrow engraftment and alters the presentation of graft-vs-host disease.
Academic Article	Reversal of acute cellular rejection after renal transplantation with Campath-1H.
Academic Article	Serum protein immunogenicity: implications for liver xenografting.
Academic Article	Concomitant infusion of unmodified donor bone marrow into unconditioned recipients of intestinal allografts.
Academic Article	Outcome after steroid withdrawal in pediatric renal transplant patients receiving tacrolimus-based immunosuppression.
Academic Article	FK 506 rescue in chronic graft-versus-host-disease after bone marrow transplantation.
Academic Article	Differential survival of hamster-to-rat liver and cardiac xenografts under FK 506 immunosuppression.
Academic Article	Toward tolerance: lessons learned from liver transplantation.
Academic Article	Marked prolongation of cardiac allograft survival by dendritic cells genetically engineered with NF-kappa B oligodeoxyribonucleotide decoys and adenoviral vectors encoding CTLA4-Ig.
Academic Article	Factors associated with the development of candidemia and candidemia-related death among liver transplant recipients.
Academic Article	The antigenicity of serum proteins and their role in xenograft rejection.
Academic Article	Immunosuppression in liver transplantation: beyond calcineurin inhibitors.
Academic Article	Daily serum inflammatory cytokine (tumor necrosis factor-alpha, interleukin-6) monitoring in liver transplantation focusing on allograft rejection: a five-case report.
Academic Article	Posttransplant lymphoproliferative disorders in adult and pediatric renal transplant patients receiving tacrolimus-based immunosuppression.
Academic Article	Outcome of kidney transplantation under tacrolimus-based immunosuppression in elderly patients.
Academic Article	Epstein-Barr virus-negative post-transplant lymphoproliferative disorders: a distinct entity?
Academic Article	Perioperative donor bone marrow infusion in recipients of organ allografts.
Academic Article	Transfection with genes encoding CTLA4Ig mediated by adenoassociated virus vectors prolongs survival of heart allografts.
Academic Article	Liver transplantation for hepatitis B: what have we learned and what does the future hold?
Academic Article	Interleukin-2 and interleukin-12 mediate distinct effector mechanisms of liver allograft rejection.
Academic Article	Serum cholesterol levels in African Americans after renal transplantation under FK 506 immunosuppression.
Academic Article	Cardiac operations in solid-organ transplant recipients.
Academic Article	Progression of liver fibrosis in patients with chronic hepatitis C after orthotopic liver transplantation.
Academic Article	High-Resolution HLA Typing for Sensitized Patients: Advances in Medicine and Science Require Us to Challenge Existing Paradigms.
Academic Article	Interferon-alpha for prophylaxis of recurrent viral hepatitis C in liver transplant recipients: a prospective, randomized, controlled trial.
Academic Article	Relationship between the diagnosis, preoperative evaluation, and prognosis after orthotopic liver transplantation.
Academic Article	Hamster-to-rat bone marrow xenotransplantation and humoral graft vs. host disease.
Academic Article	Blockade of tryptophan catabolism prevents spontaneous tolerogenicity of liver allografts.
Academic Article	Neutralization of IL-12 reverses rejection of mouse liver allografts from Flt3-ligand-treated donors and is associated with suppression of both cellular and humoral responses.
Academic Article	Prospective randomized trial of tacrolimus and prednisone versus tacrolimus, prednisone, and mycophenolate mofetil: complete report on 350 primary adult liver transplantations.
Academic Article	Prolonged survival of heart allografts transduced with AAV-CTLA4Ig.
Academic Article	Cotransplantation with myeloid-derived suppressor cells protects cell transplants: a crucial role of inducible nitric oxide synthase.
Academic Article	Long-term survival of heart and liver xenografts with splenectomy and FK 506.
Academic Article	Tolerance and chimerism in liver transplantation.
Academic Article	Early recipient-donor switch of the complement type after liver xenotransplantation.
Academic Article	Three-year Outcomes in De Novo Liver Transplant Patients Receiving Everolimus With Reduced Tacrolimus: Follow-Up Results From a Randomized, Multicenter Study.
Academic Article	Quantitation of immunosuppression by tacrolimus using flow cytometric analysis of interleukin-2 and interferon-gamma inhibition in CD8(-) and CD8(+) peripheral blood T cells.
Academic Article	Impact of Orthoclone OKT3 on liver transplantation.
Academic Article	Clinical intestinal transplantation: new perspectives and immunologic considerations.
Academic Article	Combined blockade of CD28/B7 and CD40/CD40L costimulatory pathways prevents the onset of chronic rejection.
Academic Article	Outcome after steroid withdrawal in renal transplant patients receiving tacrolimus-based immunosuppression.
Academic Article	Invasive aspergillosis in liver transplant recipients: outcome comparison of therapy with amphotericin B lipid complex and a historical cohort treated with conventional amphotericin B.
Academic Article	Pretransplant xenogeneic blood transfusion combined with FK 506 prolongs hamster-to-rat liver xenograft survival.
Academic Article	Mechanisms of protection from humoral rejection by a xenografted liver.
Academic Article	Future prospects in immunosuppression for liver transplantation.
Academic Article	Pregnancy after liver transplantation with tacrolimus immunosuppression: a single center's experience update at 13 years.
Academic Article	Administration of antisense oligodeoxyribonucleotides targeting NF-kappaB prolongs allograft survival via suppression of cytotoxicity.
Academic Article	Randomised trialomania? The multicentre liver transplant trials of tacrolimus.
Academic Article	Apoptosis within spontaneously accepted mouse liver allografts: evidence for deletion of cytotoxic T cells and implications for tolerance induction.
Academic Article	A prospective randomized trial of FK506-based immunosuppression after renal transplantation.
Academic Article	Rejection triggers liver transplant tolerance: Involvement of mesenchyme-mediated immune control mechanisms in mice.
Academic Article	Immunosuppression for liver transplantation in HCV-infected patients: mechanism-based principles.
Academic Article	Varicella-zoster virus hepatitis and a suggested management plan for prevention of VZV infection in adult liver transplant recipients.
Academic Article	Pregnancy after liver transplantation under tacrolimus.
Academic Article	Replicative senescence of biliary epithelial cells precedes bile duct loss in chronic liver allograft rejection: increased expression of p21(WAF1/Cip1) as a disease marker and the influence of immunosuppressive drugs.
Academic Article	Two-year experience with FK 506 in pediatric patients.
Academic Article	Comparative in vitro studies on the immunosuppressive effects of purine and pyrimidine synthesis inhibitors.
Academic Article	Successful hamster-to-rat liver xenotransplantation under FK506 immunosuppression induces unresponsiveness to hamster heart and skin.
Academic Article	Humoral and cellular immunopathology of hepatic and cardiac hamster-into-rat xenograft rejection. Marked stimulation of IgM++bright/IgD+dull splenic B cells.
Academic Article	The role of complement component 3 (C3) in differentiation of myeloid-derived suppressor cells.
Academic Article	Variable chimerism, graft-versus-host disease, and tolerance after different kinds of cell and whole organ transplantation from Lewis to brown Norway rats.
Academic Article	Abrogation of chronic rejection in a murine model of aortic allotransplantation by prior induction of donor-specific tolerance.
Academic Article	Presensitization by skin grafting from major histocompatibility complex class I or major histocompatibility complex class II deficient mice identifies class I antigens as inducers of allosensitization.
Academic Article	Il-12 antagonism enhances apoptotic death of T cells within hepatic allografts from Flt3 ligand-treated donors and promotes graft acceptance.
Academic Article	Rituximab (chimeric anti-CD20 antibody) for posttransplant lymphoproliferative disorder after solid organ transplantation in adults: long-term experience from a single center.
Academic Article	Immunoglobulin G lymphocytotoxic antibodies in clinical liver transplantation: studies toward further defining their significance.
Academic Article	Blockade of the CD40-CD40 ligand pathway potentiates the capacity of donor-derived dendritic cell progenitors to induce long-term cardiac allograft survival.
Academic Article	Regulatory dendritic cells modulate immune responses via induction of T-cell apoptotic death.
Academic Article	Immune regulatory activity of liver-derived dendritic cells generated in vivo.
Academic Article	Current status of intestinal transplantation in children.
Academic Article	Orthotopic liver transplantation in high-risk patients: risk factors associated with mortality and infectious morbidity.
Academic Article	Mechanistic insights into impaired dendritic cell function by rapamycin: inhibition of Jak2/Stat4 signaling pathway.
Academic Article	OKT3 in the reversal of acute hepatic allograft rejection.
Academic Article	De novo breast cancer in patients with liver transplantation: University of Pittsburgh's experience and review of the literature.
Academic Article	Alopecia as a consequence of tacrolimus therapy.
Academic Article	Sirolimus for rescue and primary immunosuppression in transplanted children receiving tacrolimus.
Academic Article	Tacrolimus (FK506) and the pharmaceutical/academic/regulatory gauntlet.
Academic Article	Metabolic changes in the recipient after successful liver xenotransplantation in the rat.
Academic Article	Cytidine potentiates the inhibitory effect of brequinar sodium on xeno-MLR, antibody production, and concordant hamster to rat cardiac xenograft survival.
Academic Article	Management of posttransplant lymphoproliferative disease in pediatric liver transplant recipients receiving primary tacrolimus (FK506) therapy.
Academic Article	Application of recipient-derived dendritic cells to induce donor-specific T-cell hyporesponsiveness.
Academic Article	Efficacy of hepatic transplantation in patients with primary sclerosing cholangitis.
Academic Article	Pediatric renal transplantation under tacrolimus-based immunosuppression.
Academic Article	A prospective, randomized trial of tacrolimus/prednisone vs tacrolimus/prednisone/mycophenolate mofetil in renal transplantation: 1-year actuarial follow-up.
Academic Article	Impact of anti-hepatitis Bc-positive grafts on the outcome of liver transplantation for HBV-related cirrhosis.
Academic Article	Complement mediated hepatocytes injury in a model of autoantibody induced hepatitis.
Academic Article	Cytidine potentiates the inhibitory effect of brequinar sodium on concordant cardiac xenograft rejection.
Academic Article	Split tolerance induced by orthotopic liver transplantation in mice.
Academic Article	Sequential infiltration of class I and class II specific alloreactive T cells in human cardiac allografts.
Academic Article	Conversion of liver allograft recipients from cyclosporine to FK506 immunosuppressive therapy--a clinicopathologic study of 96 patients.
Academic Article	A clinicopathological study of human liver allograft recipients harboring preformed IgG lymphocytotoxic antibodies.
Academic Article	Chimerism and xenotransplantation. New concepts.
Academic Article	Interactions between bronchoalveolar lymphocytes and macrophages in heart-lung transplant recipients.
Academic Article	Recipient pretreatment with mammalian IL-10 prolongs mouse cardiac allograft survival by inhibition of anti-donor T cell responses.
Academic Article	Highlights of the Festschrift in honor of Thomas E. Starzl, MD, PHD.
Academic Article	Alemtuzumab induction and tacrolimus monotherapy in pancreas transplantation: One- and two-year outcomes.
Academic Article	Should HLA mismatch acceptability for sensitized transplant candidates be determined at the high-resolution rather than the antigen level?
Academic Article	Contrasting effects of myeloid dendritic cells transduced with an adenoviral vector encoding interleukin-10 on organ allograft and tumour rejection.
Academic Article	Simultaneous pancreas-kidney transplantation at the University of Pittsburgh.
Academic Article	Four-color flow cytometric analysis of peripheral blood donor cell chimerism.
Academic Article	Preoperative assessment of risk in liver transplantation: a multivariate analysis in 2376 cases of the UW era.
Academic Article	Experimental animal model of graft-versus-host disease (GVHD) after small-bowel transplantation: characteristics of the model and application to developing treatment strategies.
Academic Article	Effect of coadministered lopinavir and ritonavir (Kaletra) on tacrolimus blood concentration in liver transplantation patients.
Academic Article	Tacrolimus for rescue of refractory renal allograft rejection.
Academic Article	Adjuvant bone marrow infusion in clinical organ transplant recipients.
Academic Article	Recurrent hepatitis C in liver allografts: prospective assessment of diagnostic accuracy, identification of pitfalls, and observations about pathogenesis.
Academic Article	Immunosuppression: evolution in practice and trends, 1994-2004.
Academic Article	The role of the A2a receptor agonist, regadenoson, in modulating hepatic artery flow in the porcine small-for-size liver graft.
Academic Article	A prospective randomized trial of mycophenolate mofetil in liver transplant recipients with hepatitis C.
Academic Article	A prospective, randomized trial to compare tacrolimus and prednisone with and without mycophenolate mofetil in patients undergoing renal transplantation: first report.
Academic Article	Primary adult liver transplantation under tacrolimus: more than 90 months actual follow-up survival and adverse events.
Academic Article	Enhancement of dendritic cell tolerogenicity by genetic modification using adenoviral vectors encoding cDNA for TGF beta 1.
Academic Article	Effect of hepatic dysfunction and T tube clamping on FK 506 pharmacokinetics and trough concentrations.
Academic Article	Single-center experience with primary orthotopic liver transplantation with FK 506 immunosuppression.
Academic Article	FK 506 in solid organ transplantation.
Academic Article	One thousand consecutive primary orthotopic liver transplants under FK 506: survival and adverse events.
Academic Article	Present state of immunosuppressive therapy in liver transplant recipients.
Academic Article	Kidney transplantation for end-stage renal failure in liver transplant recipients with hepatitis C viral infection.
Academic Article	Patterns of inflammatory vascular endothelial changes in murine liver grafts.
Academic Article	An attempt to induce tolerance with infusion of donor bone marrow in organ allograft recipients.
Academic Article	Reversibility of tacrolimus-induced posttransplant diabetes: an illustrative case and review of the literature.
Academic Article	Kidney transplantation under a tolerogenic regimen of recipient pretreatment and low-dose postoperative immunosuppression with subsequent weaning.
Academic Article	Outcome after steroid withdrawal in adult renal transplant patients receiving tacrolimus-based immunosuppression.
Academic Article	Posttransplant diabetes mellitus in African Americans after renal transplantation under FK 506 immunosuppression.
Academic Article	Reasons for long-term use of steroid in primary adult liver transplantation under tacrolimus.
Academic Article	Prevention of chronic rejection in mouse aortic allografts by combined treatment with CTLA4-Ig and anti-CD40 ligand monoclonal antibody.
Academic Article	Weaning of immunosuppression in long-term liver transplant recipients.
Academic Article	Porcine partial liver transplantation: a novel model of the "small-for-size" liver graft.
Academic Article	Tacrolimus without antilymphocyte induction therapy prevents pancreas loss from rejection in 123 consecutive patients.
Academic Article	Stromal cell-based immunotherapy in transplantation.
Academic Article	Immunological factors influencing liver graft survival.
Academic Article	Pregnancy after kidney and kidney-pancreas transplantation under tacrolimus: a single center's experience.
Academic Article	The effect of splenectomy on cardiac and liver xenografts in the nude rat.
Academic Article	Myeloid-derived suppressor cells as a potential therapy for experimental autoimmune myasthenia gravis.
Academic Article	De novo malignancies after intestinal and multivisceral transplantation.
Academic Article	A prospective randomized trial of tacrolimus and prednisone versus tacrolimus, prednisone, and mycophenolate mofetil in primary adult liver transplant recipients: an interim report.
Academic Article	Monitoring the patient off immunosuppression. Conceptual framework for a proposed tolerance assay study in liver transplant recipients.
Academic Article	Systemic administration of anti-interleukin-10 antibody prolongs organ allograft survival in normal and presensitized recipients.
Academic Article	Long-term results of pancreas transplantation under tacrolius immunosuppression.
Academic Article	Immune modulation in organ allograft recipients by single or multiple donor bone marrow infusions.
Academic Article	Prevention of T-cell activation by rhCTLA4-Ig and anti-CD40L monoclonal antibody results in indefinite islet allograft survival.
Academic Article	All-trans retinoic acid induces arginase-1 and inducible nitric oxide synthase-producing dendritic cells with T cell inhibitory function.
Academic Article	Effect of OKT3 on survival and rate of retransplantation.
Academic Article	Hepatic Stellate Cells Inhibit T Cells through Active TGF-ß1 from a Cell Surface-Bound Latent TGF-ß1/GARP Complex.
Academic Article	Weaning of immunosuppression in long-term recipients of living related renal transplants: a preliminary study.
Academic Article	Liver transplantation under tacrolimus in infants, children, adults, and seniors: long-term results, survival, and adverse events in 1000 consecutive patients.
Academic Article	De novo malignancies after liver transplantation: a major cause of late death.
Academic Article	Role of splenectomy in human liver transplantation under modern-day immunosuppression.
Academic Article	Clinical outcome of patients infected with hepatitis C virus infection on survival after primary liver transplantation under tacrolimus.
Academic Article	Murine liver allograft transplantation: tolerance and donor cell chimerism.
Academic Article	Predicting immunosuppressant dosing in the early postoperative period with noninvasive indocyanine green elimination following orthotopic liver transplantation.
Academic Article	Effect of t-tube clamping on the pharmacokinetics of mycophenolic acid in liver transplant patients on oral therapy of mycophenolate mofetil.
Academic Article	Treatment with CTLA4-Ig inhibits rejection of liver allografts from FIt3-ligand-treated donors.
Academic Article	Synergistic effect of cold and warm ischemia time on postoperative graft outcome in human liver transplantation.
Academic Article	FK 506 reverses acute graft-versus-host disease after allogeneic bone marrow transplantation in rats.
Academic Article	A pilot trial of tacrolimus, sirolimus, and steroids in renal transplant recipients.
Academic Article	Pediatric liver transplantation in 808 consecutive children: 20-years experience from a single center.
Academic Article	Prognostic role of plasma vascular endothelial growth factor in patients with hepatocellular carcinoma undergoing liver transplantation.
Academic Article	Lymphoma resembling Hodgkin disease after posttransplant lymphoproliferative disorder in a liver transplant recipient.
Academic Article	FK 506 dosage in human organ transplantation.
Academic Article	Studies of the hepatotrophic qualities of FK 506 and CyA.
Academic Article	Suppression of allograft rejection with FK506. I. Prolonged cardiac and liver survival in rats following short-course therapy.
Academic Article	Lymphoproliferative disorders arising under immunosuppression with FK 506: initial observations in a large transplant population.
Academic Article	Use of FK 506 in pediatric patients.
Academic Article	The side effects of FK 506 in humans.
Academic Article	Conversion from cyclosporine to FK 506 in liver allograft recipients with cyclosporine-related complications.
Academic Article	Interaction between tacrolimus and antiretroviral agents in human immunodeficiency virus-positive liver and kidney transplantation patients.
Academic Article	Preliminary report on surgical technique in hepatic parenchymal transection for liver tumors in the elderly: a lesson learned from living-related liver transplantation.
Academic Article	Inhibition of T-cell responses by hepatic stellate cells via B7-H1-mediated T-cell apoptosis in mice.
Academic Article	Near-total human face transplantation for a severely disfigured patient in the USA.
Academic Article	Detection of intrahepatic human islets following combined liver-islet allotransplantation.
Academic Article	Marked mitigation of transplant vascular sclerosis in FasLgld (CD95L) mutant recipients. The role of alloantibodies in the development of chronic rejection.
Academic Article	Functional differentiation of human cytotoxic T lymphocytes in the presence of FK 506 and CyA.
Academic Article	Assay of FK 506 in plasma.
Academic Article	Conversion of liver allograft recipients from cyclosporine to FK 506-based immunosuppression: benefits and pitfalls.
Academic Article	Effects of in vivo treatment with FK506 on natural killer cells in rats.
Academic Article	Experiences relating to management of biliary tract complications following liver transplantation in 96 cases.
Academic Article	Hamster-to-rat liver xenografts protect extrahepatic organs from rejection.
Academic Article	Posttransplant diabetes in pediatric recipients on tacrolimus.
Academic Article	Liver transplantation in patients with HIV infection.
Academic Article	Human hepatic stellate cells inhibit T-cell response through B7-H1 pathway.
Academic Article	Infectious complications after human small bowel transplantation.
Academic Article	Infections with FK 506 immunosuppression: preliminary results with primary therapy.
Academic Article	Pharmacokinetics of FK 506: preclinical and clinical studies.
Academic Article	Potentiation of the antiproliferative activity of brequinar sodium for murine lymphocytes by exogenous cytidine.
Academic Article	Reduction in the circulating pDC1/pDC2 ratio and impaired function of ex vivo-generated DC1 in chronic hepatitis B infection.
Academic Article	Presence of retinal pericyte-reactive autoantibodies in diabetic retinopathy patients.
Academic Article	Liver transplantation of American veterans under FK 506 immunosuppression: a preliminary report.
Academic Article	Nelfinavir, a protease inhibitor, increases sirolimus levels in a liver transplantation patient: a case report.
Academic Article	Effect of tacrolimus and splenectomy on engraftment and GVHD after bone marrow xenotransplantation in the reciprocal hamster to rat animal models.
Academic Article	Mouse liver transplantation tolerance: the role of hepatocytes and nonparenchymal cells.
Academic Article	Liver transplantation in a hemophilia patient with acquired immunodeficiency syndrome.
Academic Article	Hepatic Stellate Cells Directly Inhibit B Cells via Programmed Death-Ligand 1.
Academic Article	Oral glucose tolerance test in liver recipients treated with FK 506.
Academic Article	FK 506 in steroid-resistant focal sclerosing glomerulonephritis of childhood.
Academic Article	Liver, kidney, and thoracic organ transplantation under FK 506.
Academic Article	One hundred ten consecutive primary orthotopic liver transplants under FK 506 in adults.
Academic Article	Selected topics on FK 506, with special references to rescue of extrahepatic whole organ grafts, transplantation of "forbidden organs," side effects, mechanisms, and practical pharmacokinetics.
Academic Article	Recognition of major histocompatibility complex antigens on cultured human biliary epithelial cells by alloreactive lymphocytes.
Academic Article	Early events in liver allograft rejection. Delineation of sites of simultaneous intragraft and recipient lymphoid tissue sensitization.
Academic Article	Humoral rejection associated with antidonor lymphocytotoxic antibodies following liver transplantation.
Academic Article	The effect of graft function on FK506 plasma levels, dosages, and renal function, with particular reference to the liver.
Academic Article	Orthotopic liver transplantation in patients with human immunodeficiency virus and end-stage liver disease.
Academic Article	Loss of serum bicarbonate after discordant liver xenotransplantation.
Academic Article	Pathologic observations in human allograft recipients treated with FK 506.
Academic Article	The lymphocytotoxic crossmatch in liver transplantation: a clinicopathologic analysis.
Academic Article	The immunolymphatic theory of chronic rejection.
Academic Article	Prevention and restoration of second-set liver allograft rejection in presensitized mice: the role of "passenger" leukocytes, donor major histocompatibility complex antigens, and host cytotoxic effector mechanisms.
Academic Article	Liver transplantation under cyclosporine: a decade of experience.
Academic Article	Overview of FK506 in transplantation.
Academic Article	Almost total absence of chronic rejection in primary pediatric liver transplantation under tacrolimus.
Academic Article	The many faces of multivisceral transplantation.
Academic Article	Lamivudine after hepatitis B immune globulin is effective in preventing hepatitis B recurrence after liver transplantation.
Academic Article	High-dose cellular IL-10 exacerbates rejection and reverses effects of cyclosporine and tacrolimus in Mouse cardiac transplantation.
Academic Article	In vitro propagation and homing of liver-derived dendritic cell progenitors to lymphoid tissues of allogeneic recipients. Implications for the establishment and maintenance of donor cell chimerism following liver transplantation.
Academic Article	Local Inhibition of Complement Improves Mesenchymal Stem Cell Viability and Function After Administration.
Academic Article	C-C Chemokine Receptor Type 2-Dependent Migration of Myeloid-Derived Suppressor Cells in Protection of Islet Transplants.
Academic Article	Kaposi's sarcoma in two primary liver allograft recipients occurring under FK506 immunosuppression.
Academic Article	William Hunter Harridge lecture: The changing face of short-gut syndrome management.
Academic Article	Effect of Early Everolimus-Facilitated Reduction of Tacrolimus on Efficacy and Renal Function in De Novo Liver Transplant Recipients: 24-Month Results for the North American Subpopulation.
Academic Article	Limitations of current liver transplant immunosuppressive regimens: renal considerations.
Academic Article	Association Between Renal Dysfunction and Major Adverse Cardiac Events After Liver Transplantation: Evidence from an International Randomized Trial of Everolimus-Based Immunosuppression.
Academic Article	International Liver Transplantation Society Consensus Statement on Immunosuppression in Liver Transplant Recipients.
Academic Article	Re: Association Between Renal Dysfunction and Major Adverse Cardiac Events After Liver Transplantation: Evidence From an International Randomized Trial of Everolimus-Based Immunosuppression.
Award or Honor Receipt	Irvington Institute for Medical Research Fellow in Immunology
Award or Honor Receipt	Thomas Starzl Prize in Surgery and Immunology
Grant	COMBINED BONE MARROW AND ORGAN TRANSPLANTATION IN HUMANS
Grant	ORTHOTOPIC LIVER TRANSPLANTATION
Academic Article	Program death-1 immune checkpoint and tumor microenvironment in malignant liver tumors.
Academic Article	CD6 Receptor Regulates Intestinal Ischemia/Reperfusion-induced Injury by Modulating Natural IgM-producing B1a Cell Self-renewal.
Academic Article	Induction Therapy With Antithymocyte Globulin and Delayed Calcineurin Inhibitor Initiation for Renal Protection in Liver Transplantation: A Multicenter Randomized Controlled Phase II-B Trial.
Concept	Calcineurin Inhibitors

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